by Dr.Harald Wiesendanger– Klartext
What the mainstream media is hiding
A combination of six natural, inexpensive, over-the-counter active ingredients reduces the likelihood of developing cancer at some point in life by 90%. Four additional substances reduce it even further. An American doctor has confirmed this good news with a comprehensive review—much to the chagrin of the pharmaceutical industry, which generates € 350 billion in annual sales with oncology drugs.
There is no such person as “Dr. Justus R. Hope.” Behind this pseudonym is a US doctor who has been thinking ahead for years in his own blog, where conventional medicine reaches its limits. He has been dealing with the subject of cancer in depth since fate cruelly confronted him with it: his father died of pancreatic cancer and a close friend succumbed to a brain tumor. “These experiences,” he says, “have shaped my commitment to developing measures that are both maximally effective and realistically implementable.”
What he subsequently developed over time—in part together with renowned intensive care physician Paul E. Marik (1)—is presented by Dr. Hope in eight detailed articles (2): a sophisticated concept called “ROOT.” Apparently, it provides amazingly effective cancer prevention through a daily cocktail of dietary supplements—evidence-based, supported by a large number of current, high-quality studies from around the world. And tested in a self-experiment: Hope himself has been following his own guidelines for a long time.
How to eat your way to cancer
In 2025, more than 21 million people worldwide were diagnosed with cancer, and around 10 million died from it. By 2050, the number of new cases is expected to double, much to the delight of drug manufacturers, their investors, and shareholders. In Western industrialized countries, the average risk of developing cancer at some point in life is currently around 40% – meaning that sooner or later, two out of five people will be affected.
“Modern” Western eating habits increase the risk considerably. Not only the notorious “schnitzel, burger, and fries diet,” with lots of red meat and trans fats, but also sausage and other highly processed products provide nasty carcinogens. The dose-response relationship is clear and alarming: every daily serving of 50 g—equivalent to two slices of salami—increases the risk of colon cancer by 18% in the long term. Three such servings cause an increase of 54 to 100%. “From a biochemical point of view, eating a salami sandwich is equivalent to smoking cigarettes; it systematically triggers the molecular cascades that transform normal cells into malignant tumors,“ warns Dr. Hope.
Sugary drinks are also cancer accelerators. They ”create a metabolic environment that systematically promotes cancer growth in multiple organ systems.” Three cola drinks per day, which provide 120–140 g of added sugar and high-fructose corn syrup, increase the risk of breast cancer by 30 to 40% and colon cancer by 17%.
Even moderate consumption of processed foods increases the risk of cancer to 50 to 55%. Eating a “Big Mac” diet three times a day increases it to 60 to 70%, and a “salami sandwich” diet at every meal to 70 to 75%. This means that the probability of developing cancer is then almost 3 to 4. “The choice between these diets is clinically irrelevant,” Hope clarifies. “Both increase the overall risk of cancer by 2 to 3 times and have devastating long-term health consequences. Choosing the ‘lesser evil’ is comparable to debating whether smoking 1.5 packs a day is significantly safer than smoking 2 packs a day – both are disastrous.”
Cocktail of natural active ingredients
But even if you maintain a harmful diet, you could prevent cancer with supplements with astonishing effectiveness. Although the risk remains significantly increased, the right supplements offer at least a partial safety net. Hope recommends – with detailed explanations that can be found in his original works cited above –
1. EGCG
EGCG stands for epigallocatechin gallate, the main active ingredient in green tea. It protects cells from free radicals, which cause DNA damage through oxidative stress and can thus trigger cancer. It inhibits inflammation, stops the formation of new blood vessels for tumors, and can specifically kill cancer cells without attacking healthy cells. Studies suggest a lower risk of breast, oral, or colon cancer.
Hope’s recommendation: 400–800 mg daily, equivalent to 8–12 cups of green tea. “Proven safe through tea consumption.”
2. Curcumin
Curcumin, the yellow pigment in turmeric, has powerful anti-inflammatory and antioxidant properties—both of which are processes involved in the development of many types of cancer. In laboratory and animal studies, curcumin slows the growth of tumor cells, disrupts signals for uncontrolled cell growth, and promotes the programmed death of “defective” cells. Initial small-scale studies in humans suggest that curcumin can influence precancerous lesions, such as changes in the intestinal mucosa in people at risk.
Hope’s recommendation: 500–1000 mg of curcumin daily with piperine to improve bioavailability. “Well tolerated up to 8000 mg.”
3. Vitamin D3
Vitamin D3 helps prevent cancer by regulating cell growth and division—like an internal guardian that prevents cells from getting out of control and forming malignant tumors. It reduces inflammation and oxidative stress in the body, which reduces DNA damage. According to studies, it reduces cancer mortality by up to 12% when taken daily in low doses.
Hope’s recommendation: 1000–2000 IU daily. “Safe up to 4000 IU,” i.e., 0.1 milligrams. He considers a temporary higher dose of up to 10,000 units per day and more to be appropriate if laboratory tests show low levels.
Hope describes these three remedies as “fundamental and essential. They are all inexpensive, readily available to everyone, and extremely safe as long as the precautions listed in our treatment protocols are followed.”
4. Omega 3
Omega-3 fatty acids act as a natural anti-inflammatory in the body: they dampen chronic inflammation that damages cells and promotes cancer, similar to a fire extinguisher on smoldering fires. They also block the formation of new blood vessels for tumors and promote cell death in cancer cells while sparing healthy cells—studies show a reduction in cancer risk of up to 30%, especially for colon and breast cancer. In combination with vitamin D and exercise, the effect is even greater, at 61%.
Hope’s recommendation: 1000–2000 mg daily.
5. AGE
“AGE” stands for Aged Garlic Extract: a standardized garlic preparation that is created when garlic is allowed to “mature” over many months in a water-ethanol process instead of being processed fresh. This produces a less odorous, more stomach-friendly extract. AGE protects against cancer by intercepting free radicals and reducing oxidative stress with its ingredients such as S-allyl cysteine—like an invisible protective shield for DNA. AGE also inhibits the growth of cancer cells, for example in stomach, colon, or breast cancer, reduces inflammation, and strengthens the immune system by activating natural killer cells. Studies indicate a lower risk of stomach and colon cancer, especially with regular consumption.
Hope’s recommendation: 2.4 ml daily.
When combined, these five active ingredients reduce the lifetime risk of cancer from 65–75% to 32–39%, explains Dr. Hope. “All can be taken once a day with a meal. Excellent safety: no significant interactions, minimal side effects.”
6. Sulforaphane
Sulforaphane, found primarily in broccoli, activates the body’s own “protective switch” Nrf2, which boosts antioxidants and protects cells from harmful free radicals—like an internal cleaning robot that prevents DNA damage that can cause cancer. It inhibits the growth of cancer cells by blocking their division, promoting cell death, and preventing new blood vessels from forming in tumors, and is particularly effective in breast, colon, and prostate cancer.
Hope’s recommendation: about 20 to
50 mg daily. Higher doses may cause mild gastrointestinal discomfort such as flatulence, nausea, vomiting, or bloating. People with thyroid problems or iodine deficiency should be cautious, as very high amounts—over 100 mg/day—may interfere with iodine absorption.
7. Berberine
Berberine, a yellow plant substance from barberry or goldthread—also known as Chinese goldthread, a medicinal plant used in traditional Chinese medicine—slows down inflammatory processes and oxidative stress in the body, which damages cells and promotes cancer. It interferes with the growth of malignant tumors by blocking cell division, triggering programmed cell death, and preventing the formation of new blood vessels for tumors. It has been particularly effective in studies on breast, colon, and prostate cancer. Preliminary research suggests a lower risk of cancer, mainly due to anti-inflammatory and immune-boosting effects.
Side effects: Diarrhea/constipation in 20-30% of users; interactions with other medications. Dr. Hope advises caution, especially with statins and antidepressants; higher doses may lead to vitamin B12 deficiency. Pregnant women should avoid berberine because it can damage the brain of the unborn child.
Hope’s recommendation: 500 mg 2–3 times daily, for a total of 1000–1500 mg/day.
Justus Hope does not want to completely abandon pharmaceuticals. He swears by three additional, long-proven active ingredients.
Fighting cancer before it develops — Hope’s three favorite pharmaceuticals:
8. Celecoxib
Celecoxib (Celebrex), a selective COX-2 inhibitor (3), is suitable for cancer prevention because it reduces inflammation that chronically damages cells and promotes tumors – like a fire extinguisher against inflammatory hot spots in the body. It blocks the production of harmful prostaglandins—hormone-like lipid compounds; it inhibits the growth and spread of cancer cells—especially in colon, breast, or prostate cancer; it promotes their death and prevents new blood vessels from forming for tumors. Clinically approved for reducing colon polyps in high-risk patients, it lowers the risk of cancer in studies. However, overdose makes heart attacks or strokes more likely because it promotes the formation of thromboses.
Hope’s recommendation: 200 mg daily, gradually increasing to a maximum of 400 mg/day only if necessary, after careful consideration of the risks.
9. Ivermectin
In laboratory and animal studies, this tried-and-tested antiparasitic agent interferes with signaling pathways such as PAK1 or WNT in cancer cells, inhibits their growth, triggers autophagy, and promotes cell death. Proponents such as Justus Hope value it as a cheap, approved drug with a broad effect on many types of cancer—e.g., lung and breast cancer—that reduces inflammation and strengthens the immune system.
Hope’s recommendation: 12 mg three times a week.
10. Mebendazole
Mebendazole, a long-proven anti-worm agent, blocks the formation of microtubules in cancer cells in laboratory and animal experiments – like a saboteur that interrupts the “rails” for cell division and thus prevents uncontrolled tumor growth. It easily crosses the blood-brain barrier, inhibits cancer cells in gliomas or meningiomas, promotes apoptosis (cell death), and reduces angiogenesis in tumors. Clinical phase I studies are ongoing and indicate good tolerability.
Hope’s recommendation: “100 mg twice daily, twice a week: Take for two weeks, then take a two-week break.“
This cocktail of ten ingredients ”reduces the overall risk of cancer by 93%,“ explains Hope. ”In addition, the addition of these active ingredients increases the blocking of the entire tumor stem cell signaling pathway (…) to 97-99%.“ (4)Cancer ”is fought before it develops.”
But aren’t 5 to 10% of all cancers considered to be genetic? This does not mean that genetic makeup inevitably forces their onset. What is inherited is a predisposition due to certain genetic changes. Whether it ever manifests itself depends on many factors—a healthy lifestyle, supported by dietary supplements, could largely keep these factors in check.
However, readers should definitely take note of Hope’s “disclaimer” as a precaution: His ROOT concept is “not a substitute for medical treatment. Consult a doctor before use, especially if you are pregnant, immunocompromised, or taking blood thinners. Discontinue use if side effects occur.”
And beyond supplements?
Those who abandon carcinogenic eating habits and switch to a Mediterranean diet reduce their cancer risk by 50 to 66% even without all these supplements, as Dr. Hope points out: “This is one of the most effective preventive measures in medicine—it rivals or even surpasses the benefits of many pharmaceutical measures, and all through a change in diet.”
Want even more cancer protection? Then, “I would kindly ask you to fast overnight for 16 hours two or three days a week” and “do simple strength training regularly at home.”
And all of this combined? It doesn’t guarantee protection against cancer, but it does make it less likely.
If the “ROOT” concept catches on, what would that mean for the sales prospects of the oncology branch of the medical industry? Nothing good, much to the schadenfreude of health-conscious people.
Notes
Please note KLARTEXT’s disclaimer regarding health topics such as this one.
(1) Paul E. Marik, a long-time professor at Eastern Virginia Medical School, was a co-founder and leading voice of the Front Line COVID-19 Critical Care Alliance (FLCCC) – recently renamed the Independent Medical Alliance (IMA) – an initiative of medical professionals that promoted unconventional prevention and treatment protocols for COVID-19, including ivermectin.
(2) https://justusrhope.substack.com/p/how-to-reduce-cancer-risk-by-90-using?publication_id=837363&post_id=184241549&isFreemail=true&r=kzlh5&triedRedirect=true; https://www.onedaymd.com/2025/04/root-detox-protocol-daily-pills-that.html; https://cancertreatmentsresearch.com/cancer-prevention-with-repurposed-drugs/, https://cancertreatmentsresearch.com/the-hope-protocol-for-cancer-prevention/,
https://cancertreatmentsresearch.com/?s=mebendazole; https://justusrhope.substack.com/p/ai-uses-ivermectinmebendazole-to; https://www.onedaymd.com/2025/11/ROOT-protocols-cancer-prevention.html, https://doi.org/10.71189/JIM/2025/V01N04A02.
(3) Selective COX-2 inhibitors are anti-inflammatory drugs (NSAIDs) that specifically block the enzyme cyclooxygenase-2 (COX-2), which is increasingly active during inflammation and produces painful prostaglandins – like a targeted arrow that only hits the “arsonist” without disturbing the “caretaker” COX-1. COX-1, on the other hand, protects the stomach and kidneys, which is why these active ingredients (e.g., celecoxib) cause fewer stomach ulcers than classic NSAIDs. Disadvantage: They increase the risk of heart attacks or strokes because they indirectly promote thrombosis formation.
(4) This refers to central signaling pathways in cancer stem cells (CSCs) that are responsible for their self-renewal, resistance to therapy, and tumor growth—like a “command center” for the most resistant cancer cells. Laypeople often imagine a tumor as a “clump of identical cells,” but it is more like a city with very different inhabitants. In this city, there is a small group of “specialists” who are particularly unpleasant. Like queens in an ant colony: it is not the mass of workers that determines the survival of the colony, but the few who can repeatedly produce new supplies. Like a master key in a hotel: whoever has it can open many doors. These are cancer stem cells (CSCs). “Stem” here means that they can renew themselves, adapt under stress, and “reproduce” many different tumor cells. They are often associated with relapses and resistance to therapy.